ABSTRACT
OBJECTIVE:To investigate rules and characteristics of the adverse drug reactions(ADR)induced by monoclonal antibodies,and provide reference for rational drug use. METHODS:The literatures of ADR induced by monoclonal antibodies from Jan. 1979 to Dec. 2014 were retrieved and analyzed. RESULTS:Among the 132 ADRs induced by monoclonal antibodies,57 were male(43.18%),75 were female(56.82%),the ratio of male to female was 1∶1.3,the youngest was 2 years old,and oldest was 111 years old;Adalimumab dominated monoclonal antibody drugs(70 cases,53.03%);there were a maximum of ADR(44) within 1 d,accounting for 33.33%;ADR induced by monoclonal antibodies mainly were skin lesions (20.72%),systemic reac-tions(18.42%)and cardiovascular system damage(16.78%),with the specific performance of rash,itching,chills,fever,palpi-tation,rapid heartbeat and so on. CONCLUSIONS:ADR induced by monoclonal antibodies is more common in the clinic. The clin-ic should timely promote and strengthen the patients' care to ensure safe drug use and improve level of clinical treatment.
ABSTRACT
Objective To study the characteristics of pointing movement time for targets with different position in front of human body,to detect the effects of targets location on pointing movement time.Methods A pointing movement experiment of human arm was designed and carried out.By the statistic analysis of the experimental data,the relationship between pointing movement time and target position was discussed.Results It was shown that the starting point position and target position extremely affected the pointing movement time.Conclusion When a right-handed person touches the different targets,both the direction to target and the starting point position(target-circle location) would affect the pointing movement time extremely.When the position of the starting point changed by horizontal or vertical,the pointing movement time is more changeful by horizontal than that by vertical.To compare the pointing movement time for each target on a target-circle,the pointing movement time for right-upper target is the shortest.When the starting point is located on the right side of human body,all pointing movement time of that target-circle is the shortest.
ABSTRACT
Objective To study pointing movement characteristics and ergonomics when human upper limb touches different targets on the front board. Methods An experiment was designed, in which the data of motion duration, peak velocity, trajectory length and peak power at shoulder and elbow joint were collected. Results By analysis of the experimental results, the pointing movement characteristics among the different regions on the front board were disclosed preliminarily. Conclusion When a right-handed person touches a target on the front board, the pointing movement ergonomics on left-upper region is the best, while that on right-lower region is the worst.